Assay Detail
Binding
CHEMBL1831776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.58 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1830698 | — | — | 1 | 4.77 |
| CHEMBL1830707 | — | — | 1 | 4.55 |
| CHEMBL1830711 | — | — | 1 | 4.52 |
| CHEMBL1830693 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1830698 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1830707 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1830711 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1830693 | — | IC50 | = | 33000.0 | nM | 4.48 |