Assay Detail
Binding
CHEMBL1831952
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Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.64 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.89 |
| CHEMBL1830935 | — | — | 1 | 6.64 |
| CHEMBL66115 | DOXECITINE | 2.0 | 1 | 5.96 |
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | — | 1 | 5.68 |
| CHEMBL1830934 | — | — | 1 | 5.64 |
| CHEMBL335538 | — | — | 1 | 5.50 |
| CHEMBL477486 | DEOXYGUANOSINE TRIPHOSPHATE | — | 1 | 5.38 |
| CHEMBL1830933 | — | — | 1 | 4.82 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | Kd | = | 130.0 | nM | 6.89 |
| CHEMBL1830935 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL66115 | DOXECITINE | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | Kd | = | 2100.0 | nM | 5.68 |
| CHEMBL1830934 | — | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL335538 | — | Kd | = | 3200.0 | nM | 5.50 |
| CHEMBL477486 | DEOXYGUANOSINE TRIPHOSPHATE | Kd | = | 4200.0 | nM | 5.38 |
| CHEMBL1830933 | — | Kd | = | 15000.0 | nM | 4.82 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | Kd | = | 55000.0 | nM | 4.26 |