Assay Detail
Binding
CHEMBL1832053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3'-azido-2',3'-dideoxypurine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.10 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335538 | — | — | 1 | 5.60 |
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | — | 1 | 5.54 |
| CHEMBL66115 | DOXECITINE | 2.0 | 1 | 5.52 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | -1.0 | 1 | 4.75 |
| CHEMBL1830934 | — | — | 1 | 4.70 |
| CHEMBL1830933 | — | — | 1 | 4.51 |
| CHEMBL477486 | DEOXYGUANOSINE TRIPHOSPHATE | — | 1 | - |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | - |
| CHEMBL1830935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335538 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL220940 | THYMIDINE_TRIPHOSPHATE | Kd | = | 2900.0 | nM | 5.54 |
| CHEMBL66115 | DOXECITINE | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL1230 | LAMIVUDINE TRIPHOSPHATE | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL1830934 | — | Kd | = | 20000.0 | nM | 4.70 |
| CHEMBL1830933 | — | Kd | = | 31000.0 | nM | 4.51 |
| CHEMBL477486 | DEOXYGUANOSINE TRIPHOSPHATE | Kd | - | — | - | |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | Kd | > | 60000.0 | nM | - |
| CHEMBL1830935 | — | Kd | > | 60000.0 | nM | - |