Assay Detail
Functional
CHEMBL1832182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against P-gp overexpressing human NCI/ADR-RES cells after 96 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI/ADR-RES |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.29 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1830231 | — | — | 1 | 8.40 |
| CHEMBL1830233 | — | — | 1 | 7.96 |
| CHEMBL1830203 | — | — | 1 | 7.89 |
| CHEMBL459773 | — | — | 1 | 7.89 |
| CHEMBL1830219 | — | — | 1 | 7.85 |
| CHEMBL1830241 | — | — | 1 | 7.68 |
| CHEMBL1830237 | — | — | 1 | 7.60 |
| CHEMBL1830198 | — | — | 1 | 7.57 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.24 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.95 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1830231 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1830233 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1830203 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL459773 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1830219 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1830241 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1830237 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1830198 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1113.0 | nM | 5.95 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6263.0 | nM | 5.20 |