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Assay Detail

CHEMBL1832230

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTS assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-MC
Confidence 1 — Organism
Curated By Autocuration

Target

SK-N-MC (CHEMBL614163)
Type CELL-LINE
Organism Homo sapiens

Publication

Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.
Stefani C, Punnia-Moorthy G, Lovejoy DB, Jansson PJ, Kalinowski DS, Sharpe PC, Bernhardt PV, Richardson DR.
J Med Chem (2011) 54 : 6936 -6948
PubMed 21846118 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 7.34 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL385064 1 8.40
CHEMBL1828759 1 8.15
CHEMBL1828760 1 8.10
CHEMBL1828758 1 8.10
CHEMBL230593 1 8.05
CHEMBL1828756 1 8.05
CHEMBL1828755 1 8.05
CHEMBL1828761 1 8.05
CHEMBL1828757 1 8.00
CHEMBL1828754 1 8.00
CHEMBL1828753 1 8.00
CHEMBL1828752 1 7.96
CHEMBL442071 1 7.92
CHEMBL1828751 1 7.89
CHEMBL1828750 1 7.66
CHEMBL231621 1 7.62
CHEMBL1828749 1 6.76
CHEMBL1828748 1 6.49
CHEMBL1828747 1 6.45
CHEMBL1828746 1 5.60
CHEMBL390195 1 5.60
CHEMBL231041 1 5.25
CHEMBL556 DEFEROXAMINE 4.0 1 4.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL385064 IC50 = 4.0 nM 8.40
CHEMBL1828759 IC50 = 7.0 nM 8.15
CHEMBL1828760 IC50 = 8.0 nM 8.10
CHEMBL1828758 IC50 = 8.0 nM 8.10
CHEMBL230593 IC50 = 9.0 nM 8.05
CHEMBL1828756 IC50 = 9.0 nM 8.05
CHEMBL1828755 IC50 = 9.0 nM 8.05
CHEMBL1828761 IC50 = 9.0 nM 8.05
CHEMBL1828757 IC50 = 10.0 nM 8.00
CHEMBL1828754 IC50 = 10.0 nM 8.00
CHEMBL1828753 IC50 = 10.0 nM 8.00
CHEMBL1828752 IC50 = 11.0 nM 7.96
CHEMBL442071 IC50 = 12.0 nM 7.92
CHEMBL1828751 IC50 = 13.0 nM 7.89
CHEMBL1828750 IC50 = 22.0 nM 7.66
CHEMBL231621 IC50 = 24.0 nM 7.62
CHEMBL1828749 IC50 = 172.0 nM 6.76
CHEMBL1828748 IC50 = 321.0 nM 6.49
CHEMBL1828747 IC50 = 356.0 nM 6.45
CHEMBL1828746 IC50 = 2534.0 nM 5.60
CHEMBL390195 IC50 = 2530.0 nM 5.60
CHEMBL231041 IC50 = 5589.0 nM 5.25
CHEMBL556 DEFEROXAMINE IC50 = 22700.0 nM 4.64