Assay Detail
Binding
CHEMBL1832250
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Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSA
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: design, synthesis and biological effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.19 | 10.52 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829844 | — | — | 1 | 10.52 |
| CHEMBL1475 | TRIOXSALEN | 4.0 | 1 | 9.30 |
| CHEMBL173365 | — | — | 1 | 9.00 |
| CHEMBL53569 | ANGELICIN | — | 1 | 8.60 |
| CHEMBL164660 | PSORALEN | 1.0 | 1 | 8.52 |
| CHEMBL1829845 | — | — | 1 | - |
| CHEMBL1829846 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829844 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL1475 | TRIOXSALEN | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL173365 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL53569 | ANGELICIN | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL164660 | PSORALEN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1829845 | — | Inhibition | - | % | - | |
| CHEMBL1829846 | — | Inhibition | - | % | - |