Assay Detail
Binding
CHEMBL1832520
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Competitive inhibition of HDAC1 using KI-104 as substrate by fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.81 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.60 |
| CHEMBL1830536 | — | — | 1 | 8.11 |
| CHEMBL1830537 | — | — | 1 | 8.00 |
| CHEMBL491316 | — | — | 1 | 7.96 |
| CHEMBL1830420 | — | — | 1 | 7.96 |
| CHEMBL489332 | — | — | 1 | 7.92 |
| CHEMBL460963 | — | — | 1 | 7.82 |
| CHEMBL1830424 | — | — | 1 | 7.72 |
| CHEMBL1830422 | — | — | 1 | 7.70 |
| CHEMBL1830397 | — | — | 1 | 7.62 |
| CHEMBL1830396 | — | — | 1 | 7.58 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.58 |
| CHEMBL3215861 | — | — | 1 | 7.55 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL1830536 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL1830537 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL491316 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL1830420 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL489332 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL460963 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1830424 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1830422 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL1830397 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1830396 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL408513 | BELINOSTAT | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL3215861 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL98 | VORINOSTAT | Ki | = | 60.0 | nM | 7.22 |