Assay Detail
Binding
CHEMBL1832706
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Inhibition of microsomal PGES
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel human mPGES-1 inhibitors identified through structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.87 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29097 | — | — | 1 | 5.80 |
| CHEMBL7162 | NS-398 | — | 1 | 4.70 |
| CHEMBL15770 | SULINDAC | 4.0 | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29097 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL7162 | NS-398 | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL15770 | SULINDAC | IC50 | = | 80000.0 | nM | 4.10 |