Assay Detail
Functional
CHEMBL1833010
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Antiproliferative activity against human HUVEC cells after 24 hrs by MTT assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 4.23 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562076 | — | — | 1 | 4.82 |
| CHEMBL1829027 | — | — | 1 | 4.49 |
| CHEMBL1829029 | — | — | 1 | 4.42 |
| CHEMBL1829028 | — | — | 1 | 4.41 |
| CHEMBL562336 | — | — | 1 | 4.33 |
| CHEMBL16901 | HONOKIOL | — | 1 | 4.28 |
| CHEMBL89700 | METHYLHONOKIOL | — | 1 | 4.25 |
| CHEMBL90397 | — | — | 1 | 4.21 |
| CHEMBL1828995 | — | — | 1 | 4.19 |
| CHEMBL1829022 | — | — | 1 | 4.18 |
| CHEMBL1829017 | — | — | 1 | 4.17 |
| CHEMBL1829020 | — | — | 1 | 4.17 |
| CHEMBL1829019 | — | — | 1 | 4.15 |
| CHEMBL1829006 | — | — | 1 | 4.13 |
| CHEMBL1829021 | — | — | 1 | 4.13 |
| CHEMBL1829005 | — | — | 1 | 4.12 |
| CHEMBL1828634 | — | — | 1 | 4.11 |
| CHEMBL1829003 | — | — | 1 | 4.10 |
| CHEMBL1828994 | — | — | 1 | 4.10 |
| CHEMBL1829004 | — | — | 1 | 4.09 |
| CHEMBL1829030 | — | — | 1 | 4.06 |
| CHEMBL1829018 | — | — | 1 | 4.05 |
| CHEMBL1829014 | — | — | 1 | - |
| CHEMBL1829023 | — | — | 1 | - |
| CHEMBL89828 | — | — | 1 | - |
| CHEMBL1829024 | — | — | 1 | - |
| CHEMBL1829025 | — | — | 1 | - |
| CHEMBL1829026 | — | — | 1 | - |
| CHEMBL1829031 | — | — | 1 | - |
| CHEMBL1829141 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562076 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1829027 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL1829029 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL1829028 | — | IC50 | = | 39100.0 | nM | 4.41 |
| CHEMBL562336 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL16901 | HONOKIOL | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL89700 | METHYLHONOKIOL | IC50 | = | 55800.0 | nM | 4.25 |
| CHEMBL90397 | — | IC50 | = | 61800.0 | nM | 4.21 |
| CHEMBL1828995 | — | IC50 | = | 64300.0 | nM | 4.19 |
| CHEMBL1829022 | — | IC50 | = | 65500.0 | nM | 4.18 |
| CHEMBL1829017 | — | IC50 | = | 67100.0 | nM | 4.17 |
| CHEMBL1829020 | — | IC50 | = | 68200.0 | nM | 4.17 |
| CHEMBL1829019 | — | IC50 | = | 70500.0 | nM | 4.15 |
| CHEMBL1829006 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL1829021 | — | IC50 | = | 73300.0 | nM | 4.13 |
| CHEMBL1829005 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL1828634 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL1829003 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1828994 | — | IC50 | = | 79100.0 | nM | 4.10 |
| CHEMBL1829004 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL1829030 | — | IC50 | = | 86900.0 | nM | 4.06 |
| CHEMBL1829018 | — | IC50 | = | 89300.0 | nM | 4.05 |
| CHEMBL1828998 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1828999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829000 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829001 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829016 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829008 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829009 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829010 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829011 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829012 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829013 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829015 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1828997 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1828996 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1828993 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1828992 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829002 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829141 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829031 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829026 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829025 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829024 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL89828 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829023 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1829014 | — | IC50 | > | 100000.0 | nM | - |