Assay Detail
Functional
CHEMBL1833017
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Antimalarial activity against Plasmodium falciparum 3D7 assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Comparison of the reactivity of antimalarial 1,2,4,5-tetraoxanes with 1,2,4-trioxolanes in the presence of ferrous iron salts, heme, and ferrous iron salts/phosphatidylcholine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.71 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1828815 | — | — | 1 | 9.40 |
| CHEMBL1828819 | — | — | 1 | 9.30 |
| CHEMBL1828814 | — | — | 1 | 8.85 |
| CHEMBL1828818 | — | — | 1 | 8.68 |
| CHEMBL1828816 | — | — | 1 | 8.64 |
| CHEMBL1828817 | — | — | 1 | 8.52 |
| CHEMBL411646 | — | — | 1 | 8.28 |
| CHEMBL1828813 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1828815 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1828819 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1828814 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1828818 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1828816 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1828817 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL411646 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1828813 | — | IC50 | = | 10.0 | nM | 8.00 |