Assay Detail

CHEMBL1833033

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antagonist activity at recombinant rat OX1R expressed in CHO cells by FLIPR calcium based functional assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Orexin/Hypocretin receptor type 1 (CHEMBL1075232) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Orexin/Hypocretin receptor type 1 (CHEMBL1075232) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Orexin/Hypocretin receptor type 1

CHEMBL1075232

Anchored from Assay target.

Protein identity Orexin/Hypocretin receptor type 1

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Cell Type	CHO
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Orexin/Hypocretin receptor type 1 (CHEMBL1075232) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders.

Di Fabio R, Pellacani A, Faedo S, Roth A, Piccoli L, Gerrard P, Porter RA, Johnson CN, Thewlis K, Donati D, Stasi L, Spada S, Stemp G, Nash D, Branch C, Kindon L, Massagrande M, Poffe A, Braggio S, Chiarparin E, Marchioro C, Ratti E, Corsi M.
Bioorg Med Chem Lett (2011) 21 : 5562 -5567
PubMed 21831639 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	9.93	9.93

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1272307	SB-649868	2.0	1	9.93

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1272307	SB-649868	Ki	=	0.1175	nM	9.93