Assay Detail
Binding
CHEMBL1833115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAO-B expressed in baculovirus infected BTI-TN-5B1-4 cells assessed as production of hydrogen peroxide from p-tyramine after 15 mins by microplate fluorescence assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BTI-TN-5B1-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.52 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1830829 | — | — | 1 | 8.49 |
| CHEMBL1830814 | — | — | 1 | 8.15 |
| CHEMBL1830817 | — | — | 1 | 8.02 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.71 |
| CHEMBL1830818 | — | — | 1 | 7.67 |
| CHEMBL1830815 | — | — | 1 | 7.21 |
| CHEMBL1830796 | — | — | 1 | 6.85 |
| CHEMBL1830797 | — | — | 1 | 6.70 |
| CHEMBL1830827 | — | — | 1 | 6.39 |
| CHEMBL1830833 | — | — | 1 | 5.92 |
| CHEMBL1830825 | — | — | 1 | 5.75 |
| CHEMBL1501880 | — | — | 1 | 5.70 |
| CHEMBL1830816 | — | — | 1 | 5.43 |
| CHEMBL1830830 | — | — | 1 | 5.34 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.12 |
| CHEMBL1830828 | — | — | 1 | 5.06 |
| CHEMBL1830809 | — | — | 1 | 5.00 |
| CHEMBL149463 | 3-ACETYLCOUMARIN | — | 1 | 4.84 |
| CHEMBL1830808 | — | — | 1 | 4.83 |
| CHEMBL1411619 | — | — | 1 | 4.81 |
| CHEMBL1830811 | — | — | 1 | 4.76 |
| CHEMBL1830824 | — | — | 1 | 4.75 |
| CHEMBL1830800 | — | — | 1 | 4.75 |
| CHEMBL1830795 | — | — | 1 | 4.75 |
| CHEMBL379350 | — | — | 1 | 4.74 |
| CHEMBL326294 | ISATIN | — | 1 | 4.73 |
| CHEMBL1830810 | — | — | 1 | 4.67 |
| CHEMBL568385 | — | — | 1 | 4.63 |
| CHEMBL1830801 | — | — | 1 | 4.62 |
| CHEMBL1830799 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1830829 | — | IC50 | = | 3.22 | nM | 8.49 |
| CHEMBL1830814 | — | IC50 | = | 7.01 | nM | 8.15 |
| CHEMBL1830817 | — | IC50 | = | 9.47 | nM | 8.02 |
| CHEMBL972 | SELEGILINE | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL1830818 | — | IC50 | = | 21.47 | nM | 7.67 |
| CHEMBL1830815 | — | IC50 | = | 61.2 | nM | 7.21 |
| CHEMBL1830796 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1830797 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1830827 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1830833 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL1830825 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1501880 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL1830816 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL1830830 | — | IC50 | = | 4520.0 | nM | 5.34 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL1830828 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL1830809 | — | IC50 | = | 10060.0 | nM | 5.00 |
| CHEMBL149463 | 3-ACETYLCOUMARIN | IC50 | = | 14450.0 | nM | 4.84 |
| CHEMBL1830808 | — | IC50 | = | 14810.0 | nM | 4.83 |
| CHEMBL1411619 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1830811 | — | IC50 | = | 17510.0 | nM | 4.76 |
| CHEMBL1830824 | — | IC50 | = | 17780.0 | nM | 4.75 |
| CHEMBL1830800 | — | IC50 | = | 17970.0 | nM | 4.75 |
| CHEMBL1830795 | — | IC50 | = | 17720.0 | nM | 4.75 |
| CHEMBL379350 | — | IC50 | = | 18070.0 | nM | 4.74 |
| CHEMBL326294 | ISATIN | IC50 | = | 18750.0 | nM | 4.73 |
| CHEMBL1830810 | — | IC50 | = | 21630.0 | nM | 4.67 |
| CHEMBL568385 | — | IC50 | = | 23460.0 | nM | 4.63 |
| CHEMBL1830801 | — | IC50 | = | 23840.0 | nM | 4.62 |
| CHEMBL1830799 | — | IC50 | = | 27110.0 | nM | 4.57 |
| CHEMBL1830792 | — | IC50 | = | 42130.0 | nM | 4.38 |
| CHEMBL256699 | — | IC50 | = | 45520.0 | nM | 4.34 |
| CHEMBL1830834 | — | IC50 | = | 56120.0 | nM | 4.25 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 61350.0 | nM | 4.21 |
| CHEMBL1830793 | — | IC50 | = | 64170.0 | nM | 4.19 |