Assay Detail
Binding
CHEMBL1833396
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ditolylguanidine from rat liver sigma 2 receptor by scintillation counting
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Combination of two pharmacophoric systems: synthesis and pharmacological evaluation of spirocyclic pyranopyrazoles with high σ₁ receptor affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.51 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829565 | — | — | 1 | 7.40 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.38 |
| CHEMBL1171555 | — | — | 1 | 7.37 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL1829670 | — | — | 1 | 7.08 |
| CHEMBL1170546 | — | — | 1 | 6.99 |
| CHEMBL1829574 | — | — | 1 | 6.96 |
| CHEMBL1829672 | — | — | 1 | 6.72 |
| CHEMBL1829659 | — | — | 1 | 6.68 |
| CHEMBL1829671 | — | — | 1 | 6.57 |
| CHEMBL1829580 | — | — | 1 | 6.50 |
| CHEMBL1829579 | — | — | 1 | 6.47 |
| CHEMBL1829573 | — | — | 1 | 6.37 |
| CHEMBL1829668 | — | — | 1 | 6.37 |
| CHEMBL1829667 | — | — | 1 | 6.25 |
| CHEMBL1829571 | — | — | 1 | 6.24 |
| CHEMBL1829568 | — | — | 1 | 6.16 |
| CHEMBL1829577 | — | — | 1 | 6.12 |
| CHEMBL1829669 | — | — | 1 | 6.11 |
| CHEMBL1829572 | — | — | 1 | 6.08 |
| CHEMBL1829569 | — | — | 1 | 6.03 |
| CHEMBL1829578 | — | — | 1 | 6.03 |
| CHEMBL138809 | — | — | 1 | 5.89 |
| CHEMBL141209 | — | — | 1 | 5.46 |
| CHEMBL1829576 | — | — | 1 | - |
| CHEMBL1829566 | — | — | 1 | - |
| CHEMBL1829674 | — | — | 1 | - |
| CHEMBL1829673 | — | — | 1 | - |
| CHEMBL1170545 | — | — | 1 | - |
| CHEMBL1829567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829565 | — | Ki | = | 39.7 | nM | 7.40 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL1171555 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL1829670 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL1170546 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL1829574 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL1829672 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL1829659 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL1829671 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL1829580 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL1829579 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL1829573 | — | Ki | = | 428.0 | nM | 6.37 |
| CHEMBL1829668 | — | Ki | = | 429.0 | nM | 6.37 |
| CHEMBL1829667 | — | Ki | = | 557.0 | nM | 6.25 |
| CHEMBL1829571 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL1829568 | — | Ki | = | 687.0 | nM | 6.16 |
| CHEMBL1829577 | — | Ki | = | 752.0 | nM | 6.12 |
| CHEMBL1829669 | — | Ki | = | 773.0 | nM | 6.11 |
| CHEMBL1829572 | — | Ki | = | 833.0 | nM | 6.08 |
| CHEMBL1829569 | — | Ki | = | 925.0 | nM | 6.03 |
| CHEMBL1829578 | — | Ki | = | 933.0 | nM | 6.03 |
| CHEMBL138809 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL141209 | — | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL1829664 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829665 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829666 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829662 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829661 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829660 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829581 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829663 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829575 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829570 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829567 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1170545 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829673 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829674 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829566 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1829576 | — | Ki | > | 1000.0 | nM | - |