Assay Detail
Binding
CHEMBL1833422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HMG-CoA reductase using HMG-CoA as substrate by spectrophotometry in presence of NADPH
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.61 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 4.70 |
| CHEMBL486985 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503 | LOVASTATIN | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL486985 | — | IC50 | = | 30200.0 | nM | 4.52 |