Assay Detail
Binding
CHEMBL1833593
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Inhibition of 5-Lipoxygenase in arachidonic acid-stimulated human neutrophils after 15 mins by HPLC analysis in presence of A23187
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.57 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL314360 | — | — | 1 | 7.22 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.10 |
| CHEMBL1830338 | — | — | 1 | 5.80 |
| CHEMBL1830478 | — | — | 1 | 5.70 |
| CHEMBL1830477 | — | — | 1 | 5.62 |
| CHEMBL1830469 | — | — | 1 | 5.60 |
| CHEMBL1830466 | — | — | 1 | 5.58 |
| CHEMBL1830468 | — | — | 1 | 5.57 |
| CHEMBL1830472 | — | — | 1 | 5.55 |
| CHEMBL1830463 | — | — | 1 | 5.55 |
| CHEMBL1830464 | — | — | 1 | 5.54 |
| CHEMBL1830470 | — | — | 1 | 5.54 |
| CHEMBL1830465 | — | — | 1 | 5.54 |
| CHEMBL1830473 | — | — | 1 | 5.52 |
| CHEMBL1830474 | — | — | 1 | 5.48 |
| CHEMBL1830471 | — | — | 1 | 5.46 |
| CHEMBL1830479 | — | — | 1 | 5.40 |
| CHEMBL1830335 | — | — | 1 | 5.10 |
| CHEMBL1830476 | — | — | 1 | 5.10 |
| CHEMBL1830467 | — | — | 1 | 5.10 |
| CHEMBL1830459 | — | — | 1 | 4.82 |
| CHEMBL1830333 | — | — | 1 | - |
| CHEMBL1830458 | — | — | 1 | - |
| CHEMBL1830334 | — | — | 1 | - |
| CHEMBL1830480 | — | — | 1 | - |
| CHEMBL1830336 | — | — | 1 | - |
| CHEMBL1830475 | — | — | 1 | - |
| CHEMBL1830337 | — | — | 1 | - |
| CHEMBL1830339 | — | — | 1 | - |
| CHEMBL1830340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL314360 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL93 | ZILEUTON | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1830338 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1830478 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1830477 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1830469 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1830466 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1830468 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1830472 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1830463 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1830464 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1830470 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1830465 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1830473 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1830474 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1830471 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL1830479 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1830467 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1830335 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1830476 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1830459 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1830460 | — | IC50 | - | — | - | |
| CHEMBL1830461 | — | IC50 | - | — | - | |
| CHEMBL1830462 | — | IC50 | - | — | - | |
| CHEMBL1830457 | — | IC50 | - | — | - | |
| CHEMBL1830332 | — | IC50 | - | — | - | |
| CHEMBL1830343 | — | IC50 | - | — | - | |
| CHEMBL1830342 | — | IC50 | - | — | - | |
| CHEMBL1830341 | — | IC50 | - | — | - | |
| CHEMBL1830340 | — | IC50 | - | — | - | |
| CHEMBL1830339 | — | IC50 | - | — | - | |
| CHEMBL1830337 | — | IC50 | - | — | - | |
| CHEMBL1830475 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1830336 | — | IC50 | - | — | - | |
| CHEMBL1830480 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1830334 | — | IC50 | - | — | - | |
| CHEMBL1830458 | — | IC50 | - | — | - | |
| CHEMBL1830333 | — | IC50 | - | — | - |