Assay Detail
Binding
CHEMBL1833730
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Inhibition of recombinant HCV NS5B Cdelta21 polymerase assessed as [alpha-32P]UMP incorporation into RNA after 1 hr by liquid scintillation counting
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.69 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829220 | — | — | 1 | 5.62 |
| CHEMBL1829217 | — | — | 1 | 5.28 |
| CHEMBL1829214 | — | — | 1 | 5.16 |
| CHEMBL1828636 | — | — | 1 | 5.12 |
| CHEMBL1829071 | — | — | 1 | 5.09 |
| CHEMBL1829212 | — | — | 1 | 4.95 |
| CHEMBL1829213 | — | — | 1 | 4.91 |
| CHEMBL449221 | — | — | 1 | 4.83 |
| CHEMBL1829218 | — | — | 1 | 4.77 |
| CHEMBL1829073 | — | — | 1 | 4.76 |
| CHEMBL1829211 | — | — | 1 | 4.68 |
| CHEMBL1829069 | — | — | 1 | 4.66 |
| CHEMBL1829208 | — | — | 1 | 4.66 |
| CHEMBL1829210 | — | — | 1 | 4.61 |
| CHEMBL1829075 | — | — | 1 | 4.59 |
| CHEMBL1829070 | — | — | 1 | 4.53 |
| CHEMBL1829207 | — | — | 1 | 4.52 |
| CHEMBL1829076 | — | — | 1 | 4.50 |
| CHEMBL1829206 | — | — | 1 | 4.49 |
| CHEMBL1829209 | — | — | 1 | 4.42 |
| CHEMBL1829072 | — | — | 1 | 4.42 |
| CHEMBL1829216 | — | — | 1 | 4.40 |
| CHEMBL1829215 | — | — | 1 | 4.30 |
| CHEMBL1829219 | — | — | 1 | 4.30 |
| CHEMBL1829074 | — | — | 1 | 4.26 |
| CHEMBL1829077 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829220 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1829217 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1829214 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1828636 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1829071 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1829212 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL1829213 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL449221 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL1829218 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1829073 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL1829211 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL1829069 | — | IC50 | = | 21800.0 | nM | 4.66 |
| CHEMBL1829208 | — | IC50 | = | 21700.0 | nM | 4.66 |
| CHEMBL1829210 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL1829075 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL1829070 | — | IC50 | = | 29600.0 | nM | 4.53 |
| CHEMBL1829207 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL1829076 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL1829206 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL1829209 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL1829072 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL1829216 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL1829215 | — | IC50 | = | 49900.0 | nM | 4.30 |
| CHEMBL1829219 | — | IC50 | = | 49700.0 | nM | 4.30 |
| CHEMBL1829074 | — | IC50 | = | 55500.0 | nM | 4.26 |
| CHEMBL1829077 | — | IC50 | = | 63900.0 | nM | 4.19 |