Assay Detail
Binding
CHEMBL1833759
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of neutral endopeptidase in human fibroblasts homogenates using glutaryl-Ala-Ala-Phe-4-methoxy-2-naphtylamide as substrate after 1 hrs by fluorimetric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design of dipeptide derivatives for the human neutral endopeptidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.51 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829584 | — | — | 1 | 9.44 |
| CHEMBL1829585 | — | — | 1 | 9.29 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 8.70 |
| CHEMBL1829583 | — | — | 1 | 8.01 |
| CHEMBL1829587 | — | — | 1 | 6.38 |
| CHEMBL1829586 | — | — | 1 | 6.37 |
| CHEMBL1829582 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829584 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL1829585 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1829583 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL1829587 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1829586 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1829582 | — | IC50 | = | 44000.0 | nM | 4.36 |