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Assay Detail

CHEMBL1837263

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Functional
Antiproliferative activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents.
Reddy MA, Jain N, Yada D, Kishore C, Vangala JR, P Surendra R, Addlagatta A, Kalivendi SV, Sreedhar B.
J Med Chem (2011) 54 : 6751 -6760
PubMed 21851083 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 10.52 10.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1836551 1 10.82
CHEMBL1836547 1 10.79
CHEMBL1836543 1 10.72
CHEMBL1836542 1 10.64
CHEMBL1836546 1 10.57
CHEMBL1836548 1 10.54
CHEMBL1836541 1 10.44
CHEMBL1836549 1 10.39
CHEMBL1836545 1 10.39
CHEMBL165 RESVERATROL 3.0 1 10.35
CHEMBL1836550 1 10.35
CHEMBL1836544 1 10.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1836551 IC50 = 0.015 nM 10.82
CHEMBL1836547 IC50 = 0.0163 nM 10.79
CHEMBL1836543 IC50 = 0.019 nM 10.72
CHEMBL1836542 IC50 = 0.0228 nM 10.64
CHEMBL1836546 IC50 = 0.0271 nM 10.57
CHEMBL1836548 IC50 = 0.0289 nM 10.54
CHEMBL1836541 IC50 = 0.0359 nM 10.44
CHEMBL1836549 IC50 = 0.041 nM 10.39
CHEMBL1836545 IC50 = 0.0404 nM 10.39
CHEMBL165 RESVERATROL IC50 = 0.0447 nM 10.35
CHEMBL1836550 IC50 = 0.0444 nM 10.35
CHEMBL1836544 IC50 = 0.0595 nM 10.23