Assay Detail
Functional
CHEMBL1837360
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Antagonist activity at human V2 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.52 | 6.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1837041 | — | — | 1 | 6.15 |
| CHEMBL1837040 | — | — | 1 | 5.35 |
| CHEMBL1837037 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1837041 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL1837040 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1837037 | — | IC50 | = | 8490.0 | nM | 5.07 |