Assay Detail
Binding
CHEMBL1837595
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei brucei |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Trypanothione reductase (CHEMBL1837) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei |
Publication
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.74 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836603 | — | — | 1 | 5.84 |
| CHEMBL1836570 | — | — | 1 | 5.75 |
| CHEMBL1836559 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836603 | — | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL1836570 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL1836559 | — | Ki | = | 2270.0 | nM | 5.64 |