Assay Detail
ADMET
CHEMBL1837598
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Cytotoxicity against human MRC5 cells by resazurin fluorescence-based viability assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 5.01 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836603 | — | — | 1 | 5.72 |
| CHEMBL1836380 | — | — | 1 | 5.57 |
| CHEMBL1836575 | — | — | 1 | 5.47 |
| CHEMBL1836378 | — | — | 1 | 5.34 |
| CHEMBL1836615 | — | — | 1 | 5.30 |
| CHEMBL1836611 | — | — | 1 | 5.24 |
| CHEMBL1836570 | — | — | 1 | 5.22 |
| CHEMBL1836574 | — | — | 1 | 5.17 |
| CHEMBL1836572 | — | — | 1 | 5.08 |
| CHEMBL1836606 | — | — | 1 | 5.00 |
| CHEMBL1836562 | — | — | 1 | 4.92 |
| CHEMBL1836376 | — | — | 1 | 4.85 |
| CHEMBL1836559 | — | — | 1 | 4.66 |
| CHEMBL1836567 | — | — | 1 | 4.64 |
| CHEMBL1836571 | — | — | 1 | 4.64 |
| CHEMBL1836371 | — | — | 1 | 4.57 |
| CHEMBL1836368 | — | — | 1 | 4.44 |
| CHEMBL1836365 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836603 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1836380 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1836575 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1836378 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1836615 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1836611 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1836570 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1836574 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1836572 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1836606 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1836562 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1836376 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1836559 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1836567 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1836571 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1836371 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1836368 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL1836365 | — | EC50 | = | 46000.0 | nM | 4.34 |