Assay Detail
Binding
CHEMBL1837692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant GST-fused ALK5 expressed in Sf9 cells using casein as a substrate by radioisotopic protein kinase assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 8.21 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835530 | — | — | 1 | 9.24 |
| CHEMBL1835622 | — | — | 1 | 8.67 |
| CHEMBL1835522 | — | — | 1 | 8.65 |
| CHEMBL1835519 | — | — | 1 | 8.62 |
| CHEMBL1835630 | — | — | 1 | 8.60 |
| CHEMBL1835535 | — | — | 1 | 8.55 |
| CHEMBL1835112 | — | — | 1 | 8.55 |
| CHEMBL1835532 | — | — | 1 | 8.53 |
| CHEMBL1835521 | — | — | 1 | 8.52 |
| CHEMBL1835529 | — | — | 1 | 8.52 |
| CHEMBL1835623 | — | — | 1 | 8.49 |
| CHEMBL1835531 | — | — | 1 | 8.48 |
| CHEMBL1835525 | — | — | 1 | 8.46 |
| CHEMBL1835626 | — | — | 1 | 8.45 |
| CHEMBL1835624 | — | — | 1 | 8.42 |
| CHEMBL1835527 | — | — | 1 | 8.41 |
| CHEMBL1835520 | — | — | 1 | 8.40 |
| CHEMBL1835627 | — | — | 1 | 8.40 |
| CHEMBL1835621 | — | — | 1 | 8.40 |
| CHEMBL1835536 | — | — | 1 | 8.40 |
| CHEMBL1835526 | — | — | 1 | 8.39 |
| CHEMBL1835628 | — | — | 1 | 8.38 |
| CHEMBL1835629 | — | — | 1 | 8.36 |
| CHEMBL1835524 | — | — | 1 | 8.35 |
| CHEMBL1835518 | — | — | 1 | 8.35 |
| CHEMBL1835625 | — | — | 1 | 8.29 |
| CHEMBL1835534 | — | — | 1 | 8.27 |
| CHEMBL1835620 | — | — | 1 | 8.24 |
| CHEMBL1835528 | — | — | 1 | 8.18 |
| CHEMBL1835523 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835530 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL1835622 | — | IC50 | = | 2.12 | nM | 8.67 |
| CHEMBL1835522 | — | IC50 | = | 2.26 | nM | 8.65 |
| CHEMBL1835519 | — | IC50 | = | 2.37 | nM | 8.62 |
| CHEMBL1835630 | — | IC50 | = | 2.49 | nM | 8.60 |
| CHEMBL1835535 | — | IC50 | = | 2.83 | nM | 8.55 |
| CHEMBL1835112 | — | IC50 | = | 2.82 | nM | 8.55 |
| CHEMBL1835532 | — | IC50 | = | 2.95 | nM | 8.53 |
| CHEMBL1835529 | — | IC50 | = | 3.04 | nM | 8.52 |
| CHEMBL1835521 | — | IC50 | = | 3.01 | nM | 8.52 |
| CHEMBL1835623 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1835531 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1835525 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL1835626 | — | IC50 | = | 3.54 | nM | 8.45 |
| CHEMBL1835624 | — | IC50 | = | 3.78 | nM | 8.42 |
| CHEMBL1835527 | — | IC50 | = | 3.87 | nM | 8.41 |
| CHEMBL1835536 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1835621 | — | IC50 | = | 3.98 | nM | 8.40 |
| CHEMBL1835520 | — | IC50 | = | 3.98 | nM | 8.40 |
| CHEMBL1835627 | — | IC50 | = | 3.97 | nM | 8.40 |
| CHEMBL1835526 | — | IC50 | = | 4.09 | nM | 8.39 |
| CHEMBL1835628 | — | IC50 | = | 4.12 | nM | 8.38 |
| CHEMBL1835629 | — | IC50 | = | 4.37 | nM | 8.36 |
| CHEMBL1835524 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1835518 | — | IC50 | = | 4.43 | nM | 8.35 |
| CHEMBL1835625 | — | IC50 | = | 5.08 | nM | 8.29 |
| CHEMBL1835534 | — | IC50 | = | 5.39 | nM | 8.27 |
| CHEMBL1835620 | — | IC50 | = | 5.69 | nM | 8.24 |
| CHEMBL1835528 | — | IC50 | = | 6.61 | nM | 8.18 |
| CHEMBL1835523 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1835533 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL492634 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL1835709 | — | IC50 | = | 39.47 | nM | 7.40 |
| CHEMBL1824446 | — | IC50 | = | 54.4 | nM | 7.26 |
| CHEMBL1835713 | — | IC50 | = | 66.8 | nM | 7.17 |
| CHEMBL1835712 | — | IC50 | = | 85.3 | nM | 7.07 |
| CHEMBL1835710 | — | IC50 | = | 95.7 | nM | 7.02 |
| CHEMBL1835711 | — | IC50 | = | 102.0 | nM | 6.99 |