Assay Detail
Binding
CHEMBL1837693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assay
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-substituted-3-(6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.48 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492634 | — | — | 1 | 6.32 |
| CHEMBL1835709 | — | — | 1 | 6.30 |
| CHEMBL1824446 | — | — | 1 | 6.23 |
| CHEMBL1835710 | — | — | 1 | 6.22 |
| CHEMBL1835622 | — | — | 1 | 5.84 |
| CHEMBL1835624 | — | — | 1 | 5.77 |
| CHEMBL1835521 | — | — | 1 | 5.70 |
| CHEMBL1835630 | — | — | 1 | 5.61 |
| CHEMBL1835112 | — | — | 1 | 5.55 |
| CHEMBL1835625 | — | — | 1 | 5.54 |
| CHEMBL1835528 | — | — | 1 | 5.53 |
| CHEMBL1835534 | — | — | 1 | 5.52 |
| CHEMBL1835712 | — | — | 1 | 5.50 |
| CHEMBL1835535 | — | — | 1 | 5.49 |
| CHEMBL1835536 | — | — | 1 | 5.43 |
| CHEMBL1835520 | — | — | 1 | 5.43 |
| CHEMBL1835629 | — | — | 1 | 5.42 |
| CHEMBL1835623 | — | — | 1 | 5.42 |
| CHEMBL1835621 | — | — | 1 | 5.42 |
| CHEMBL1835529 | — | — | 1 | 5.38 |
| CHEMBL1835525 | — | — | 1 | 5.37 |
| CHEMBL1835533 | — | — | 1 | 5.30 |
| CHEMBL1835628 | — | — | 1 | 5.30 |
| CHEMBL1835532 | — | — | 1 | 5.28 |
| CHEMBL1835531 | — | — | 1 | 5.28 |
| CHEMBL1835627 | — | — | 1 | 5.27 |
| CHEMBL1835527 | — | — | 1 | 5.26 |
| CHEMBL1835519 | — | — | 1 | 5.26 |
| CHEMBL1835518 | — | — | 1 | 5.25 |
| CHEMBL1835626 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492634 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1835709 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL1824446 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL1835710 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL1835622 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL1835624 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL1835521 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL1835630 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL1835112 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1835625 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL1835528 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL1835534 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1835712 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1835535 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL1835520 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL1835536 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL1835629 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL1835623 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL1835621 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL1835529 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL1835525 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL1835533 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL1835628 | — | IC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL1835532 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL1835531 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL1835627 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL1835527 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL1835519 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL1835518 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL1835626 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL1835530 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL1835524 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL1835526 | — | IC50 | = | 6670.0 | nM | 5.18 |
| CHEMBL1835713 | — | IC50 | = | 6580.0 | nM | 5.18 |
| CHEMBL1835711 | — | IC50 | = | 7260.0 | nM | 5.14 |
| CHEMBL1835620 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL1835523 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1835522 | — | IC50 | > | 10000.0 | nM | - |