Assay Detail
Binding
CHEMBL1837884
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Inhibition of NF-kappaB activation expressed in TNFalpha-stimulated human HepG2 cells co-transfected with PPRE-Luc plasmid pretreated for 1 hr before TNFalpha challenge measured after 24 hrs by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.49 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 6.05 |
| CHEMBL1834950 | ELATOSIDE L | — | 1 | 5.39 |
| CHEMBL1833984 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1834950 | ELATOSIDE L | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1833984 | — | IC50 | = | 9500.0 | nM | 5.02 |