Assay Detail
Functional
CHEMBL1838231
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Antimalarial activity against Plasmodium falciparum 3D7 infected in O-positive human erythrocytes assessed as inhibition of parasite lactate dehydrogenase after 72 hrs by pLDH method
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 4.49 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835290 | — | — | 1 | 5.80 |
| CHEMBL1256629 | AMIPROPHOS METHYL | — | 1 | 5.40 |
| CHEMBL1835280 | — | — | 1 | 5.35 |
| CHEMBL1835289 | — | — | 1 | 5.16 |
| CHEMBL1835282 | — | — | 1 | 5.07 |
| CHEMBL1835291 | — | — | 1 | 4.77 |
| CHEMBL1835292 | — | — | 1 | 4.64 |
| CHEMBL1835281 | — | — | 1 | 4.58 |
| CHEMBL1835180 | — | — | 1 | 4.55 |
| CHEMBL1835277 | — | — | 1 | 4.50 |
| CHEMBL1835170 | — | — | 1 | 4.41 |
| CHEMBL1835172 | — | — | 1 | 4.41 |
| CHEMBL1835278 | — | — | 1 | 4.40 |
| CHEMBL1835283 | — | — | 1 | 4.37 |
| CHEMBL1835284 | — | — | 1 | 4.36 |
| CHEMBL1835279 | — | — | 1 | 4.35 |
| CHEMBL1835273 | — | — | 1 | 4.33 |
| CHEMBL1835285 | — | — | 1 | 4.32 |
| CHEMBL1835174 | — | — | 1 | 4.30 |
| CHEMBL1835175 | — | — | 1 | 4.30 |
| CHEMBL1835182 | — | — | 1 | 4.29 |
| CHEMBL1835287 | — | — | 1 | 4.25 |
| CHEMBL1835176 | — | — | 1 | 4.14 |
| CHEMBL1835181 | — | — | 1 | 4.12 |
| CHEMBL1835276 | — | — | 1 | 4.10 |
| CHEMBL1835167 | — | — | 1 | 4.10 |
| CHEMBL1835286 | — | — | 1 | 4.08 |
| CHEMBL1835177 | — | — | 1 | 4.06 |
| CHEMBL1835173 | — | — | 1 | 4.06 |
| CHEMBL1835288 | — | — | 1 | 4.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835290 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1256629 | AMIPROPHOS METHYL | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1835280 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1835289 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1835282 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL1835291 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1835292 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1835281 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1835180 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1835277 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1835170 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1835172 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL1835278 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1835283 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL1835284 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1835279 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL1835273 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1835285 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1835174 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1835175 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1835182 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL1835287 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL1835176 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL1835181 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL1835276 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL1835167 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL1835286 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL1835177 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL1835173 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL1835288 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL1835274 | — | IC50 | = | 102000.0 | nM | - |
| CHEMBL1835275 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL1835171 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL1835293 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL1835169 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL1835168 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL1835166 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL1835165 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL1835164 | — | IC50 | = | 128000.0 | nM | - |
| CHEMBL1835163 | — | IC50 | = | 126000.0 | nM | - |
| CHEMBL1835162 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL1835179 | — | IC50 | > | 128000.0 | nM | - |
| CHEMBL1835390 | — | IC50 | = | 102000.0 | nM | - |