Assay Detail
Functional
CHEMBL1838282
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Immunomodulatory activity in human primary B cells assessed as induction of CD69 expression after 24 hrs by FITC-conjugated flow cytometry
21
Total Activities
21
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | B cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.41 | 6.90 |
| pIC50 | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834758 | — | — | 1 | 6.90 |
| CHEMBL1834757 | — | — | 1 | 6.80 |
| CHEMBL1835065 | — | — | 1 | 6.80 |
| CHEMBL1835072 | — | — | 1 | 6.70 |
| CHEMBL1835071 | — | — | 1 | 6.60 |
| CHEMBL1835061 | — | — | 1 | 6.40 |
| CHEMBL1835070 | — | — | 1 | 6.30 |
| CHEMBL1235110 | — | — | 1 | 6.20 |
| CHEMBL1835069 | — | — | 1 | 5.70 |
| CHEMBL1835068 | — | — | 1 | 5.70 |
| CHEMBL1834756 | — | — | 1 | - |
| CHEMBL1835057 | — | — | 1 | - |
| CHEMBL1835058 | — | — | 1 | - |
| CHEMBL1835059 | — | — | 1 | - |
| CHEMBL1835060 | — | — | 1 | - |
| CHEMBL1835062 | — | — | 1 | - |
| CHEMBL515757 | — | — | 1 | - |
| CHEMBL1835064 | — | — | 1 | - |
| CHEMBL1835066 | — | — | 1 | - |
| CHEMBL1835067 | — | — | 1 | - |
| CHEMBL1835063 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834758 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL1834757 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL1835065 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL1835072 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL1835071 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL1835061 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL1835070 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL1235110 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL1835069 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL1835068 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL1834756 | — | pIC50 | - | — | - | |
| CHEMBL1835057 | — | pIC50 | - | — | - | |
| CHEMBL1835058 | — | pIC50 | - | — | - | |
| CHEMBL1835059 | — | pIC50 | - | — | - | |
| CHEMBL1835060 | — | pIC50 | - | — | - | |
| CHEMBL1835062 | — | pIC50 | - | — | - | |
| CHEMBL515757 | — | pIC50 | - | — | - | |
| CHEMBL1835064 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1835066 | — | pIC50 | - | — | - | |
| CHEMBL1835067 | — | pIC50 | - | — | - | |
| CHEMBL1835063 | — | pIC50 | - | — | - |