Assay Detail
Functional
CHEMBL1839062
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Cytotoxicity against human MCF7 cells after 48 hrs by MTS assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.03 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834930 | — | — | 1 | 5.84 |
| CHEMBL1834927 | — | — | 1 | 5.82 |
| CHEMBL1834923 | — | — | 1 | 5.78 |
| CHEMBL1834924 | — | — | 1 | 5.05 |
| CHEMBL1834922 | — | — | 1 | 5.01 |
| CHEMBL1834931 | — | — | 1 | 4.92 |
| CHEMBL1834925 | — | — | 1 | 4.83 |
| CHEMBL1834921 | — | — | 1 | 4.67 |
| CHEMBL1834926 | — | — | 1 | 4.66 |
| CHEMBL388579 | — | — | 1 | 4.65 |
| CHEMBL1834929 | — | — | 1 | 4.61 |
| CHEMBL1834928 | — | — | 1 | 4.56 |
| CHEMBL378544 | VINBLASTINE SULFATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834930 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL1834927 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL1834923 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL1834924 | — | IC50 | = | 8960.0 | nM | 5.05 |
| CHEMBL1834922 | — | IC50 | = | 9780.0 | nM | 5.01 |
| CHEMBL1834931 | — | IC50 | = | 12010.0 | nM | 4.92 |
| CHEMBL1834925 | — | IC50 | = | 14860.0 | nM | 4.83 |
| CHEMBL1834921 | — | IC50 | = | 21510.0 | nM | 4.67 |
| CHEMBL1834926 | — | IC50 | = | 22130.0 | nM | 4.66 |
| CHEMBL388579 | — | IC50 | = | 22450.0 | nM | 4.65 |
| CHEMBL1834929 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL1834928 | — | IC50 | = | 27740.0 | nM | 4.56 |
| CHEMBL378544 | VINBLASTINE SULFATE | IC50 | - | — | - |