Assay Detail
Functional
CHEMBL1839094
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Antiproliferative activity against HUVEC assessed as inhibition of cell growth after 3 days by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiangiogenic activity of new silybin galloyl esters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.11 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835937 | — | — | 1 | 5.37 |
| CHEMBL1835935 | — | — | 1 | 5.32 |
| CHEMBL1835936 | — | — | 1 | 5.22 |
| CHEMBL592675 | SILYBIN B | — | 1 | 5.19 |
| CHEMBL431701 | SILYBIN A | 3.0 | 1 | 5.05 |
| CHEMBL9509 | SILIBININ | 3.0 | 1 | 5.00 |
| CHEMBL1835938 | — | — | 1 | 4.99 |
| CHEMBL1835939 | — | — | 1 | 4.94 |
| CHEMBL1835934 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835937 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL1835935 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL1835936 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL592675 | SILYBIN B | IC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL431701 | SILYBIN A | IC50 | = | 8830.0 | nM | 5.05 |
| CHEMBL9509 | SILIBININ | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL1835938 | — | IC50 | = | 10350.0 | nM | 4.99 |
| CHEMBL1835939 | — | IC50 | = | 11590.0 | nM | 4.94 |
| CHEMBL1835934 | — | IC50 | = | 12310.0 | nM | 4.91 |