Assay Detail
Binding
CHEMBL1839320
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Inhibition of SCD1 in human HepG2 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.73 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834443 | — | — | 1 | 7.80 |
| CHEMBL1834453 | — | — | 1 | 7.77 |
| CHEMBL1834262 | — | — | 1 | 7.54 |
| CHEMBL1834452 | — | — | 1 | 7.33 |
| CHEMBL1834454 | — | — | 1 | 7.32 |
| CHEMBL1834456 | — | — | 1 | 7.28 |
| CHEMBL1834442 | — | — | 1 | 7.23 |
| CHEMBL1834447 | — | — | 1 | 6.79 |
| CHEMBL1834457 | — | — | 1 | 6.78 |
| CHEMBL1834446 | — | — | 1 | 6.74 |
| CHEMBL1834451 | — | — | 1 | 6.59 |
| CHEMBL1834441 | — | — | 1 | 6.57 |
| CHEMBL1834449 | — | — | 1 | 6.50 |
| CHEMBL1834448 | — | — | 1 | 6.42 |
| CHEMBL1834445 | — | — | 1 | 6.12 |
| CHEMBL1834450 | — | — | 1 | 4.97 |
| CHEMBL1833979 | — | — | 1 | 4.61 |
| CHEMBL1834455 | — | — | 1 | - |
| CHEMBL1834444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834443 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1834453 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1834262 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1834452 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL1834454 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1834456 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1834442 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1834447 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL1834457 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL1834446 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL1834451 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL1834441 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL1834449 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL1834448 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL1834445 | — | IC50 | = | 755.0 | nM | 6.12 |
| CHEMBL1834450 | — | IC50 | = | 10639.0 | nM | 4.97 |
| CHEMBL1833979 | — | IC50 | = | 24345.0 | nM | 4.61 |
| CHEMBL1834455 | — | IC50 | < | 39.0 | nM | - |
| CHEMBL1834444 | — | IC50 | - | — | - |