Assay Detail
Binding
CHEMBL1839476
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Inhibition of human recombinant MMP2 assessed as hydrolysis of MOCAcPLGLA2pr(Dnp)AR-NH2 by fluorescence spectrofluorometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective water-soluble gelatinase inhibitor prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.45 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834422 | — | — | 1 | 7.62 |
| CHEMBL1834418 | — | — | 1 | 7.21 |
| CHEMBL1834419 | — | — | 1 | 7.16 |
| CHEMBL1834421 | — | — | 1 | 6.38 |
| CHEMBL1834417 | — | — | 1 | 6.36 |
| CHEMBL1834420 | — | — | 1 | 6.28 |
| CHEMBL1834423 | — | — | 1 | 4.11 |
| CHEMBL485492 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834422 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL1834418 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL1834419 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL1834421 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL1834417 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL1834420 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL1834423 | — | Ki | = | 78000.0 | nM | 4.11 |
| CHEMBL485492 | — | Ki | = | 110000.0 | nM | - |