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Assay Detail

CHEMBL1839573

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Functional
Antiviral activity against Human rhinovirus 16 infected in human HeLa Ohio cells assessed as inhibition of virus-induced cytopathic effect by CellTiter-Glo assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism rhinovirus A16
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

rhinovirus A16 (CHEMBL613769)
Type ORGANISM
Organism rhinovirus A16

Publication

Effect of lipophilicity modulation on inhibition of human rhinovirus capsid binders.
Morley A, Tomkinson N, Cook A, MacDonald C, Weaver R, King S, Jenkinson L, Unitt J, McCrae C, Phillips T.
Bioorg Med Chem Lett (2011) 21 : 6031 -6035
PubMed 21907579 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.81 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1835909 1 7.70
CHEMBL1835905 1 7.60
CHEMBL1835903 1 7.50
CHEMBL298019 PIRODAVIR 2.0 1 7.20
CHEMBL1835906 1 7.20
CHEMBL1835910 1 7.20
CHEMBL1835911 1 7.20
CHEMBL1835912 1 7.20
CHEMBL1835908 1 7.10
CHEMBL1835918 1 7.10
CHEMBL1835904 1 7.00
CHEMBL1835907 1 6.80
CHEMBL29609 PLECONARIL 2.0 1 6.00
CHEMBL1835914 1 5.80
CHEMBL1835915 1 5.80
CHEMBL1835916 1 5.70
CHEMBL1835913 1 5.60
CHEMBL1835917 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1835909 IC50 = 19.95 nM 7.70
CHEMBL1835905 IC50 = 25.12 nM 7.60
CHEMBL1835903 IC50 = 31.62 nM 7.50
CHEMBL298019 PIRODAVIR IC50 = 63.1 nM 7.20
CHEMBL1835906 IC50 = 63.1 nM 7.20
CHEMBL1835910 IC50 = 63.1 nM 7.20
CHEMBL1835911 IC50 = 63.1 nM 7.20
CHEMBL1835912 IC50 = 63.1 nM 7.20
CHEMBL1835908 IC50 = 79.43 nM 7.10
CHEMBL1835918 IC50 = 79.43 nM 7.10
CHEMBL1835904 IC50 = 100.0 nM 7.00
CHEMBL1835907 IC50 = 158.49 nM 6.80
CHEMBL29609 PLECONARIL IC50 = 1000.0 nM 6.00
CHEMBL1835914 IC50 = 1584.89 nM 5.80
CHEMBL1835915 IC50 = 1584.89 nM 5.80
CHEMBL1835916 IC50 = 1995.26 nM 5.70
CHEMBL1835913 IC50 = 2511.89 nM 5.60
CHEMBL1835917 IC50 > 31622.78 nM -