Assay Detail
Binding
CHEMBL1839595
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Inhibition of human FAS assessed as synthesis of long chain fatty acids from malonyl CoA after 60 mins by fluorescence assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of BI 99179, a potent and selective inhibitor of type I fatty acid synthase with central exposure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.23 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1834184 | BI 99179 | — | 1 | 7.10 |
| CHEMBL1834182 | — | — | 1 | 6.72 |
| CHEMBL1834192 | — | — | 1 | 6.70 |
| CHEMBL1834194 | — | — | 1 | 6.57 |
| CHEMBL1834197 | — | — | 1 | 6.55 |
| CHEMBL1834185 | — | — | 1 | 6.54 |
| CHEMBL1834179 | — | — | 1 | 6.52 |
| CHEMBL1834183 | — | — | 1 | 6.51 |
| CHEMBL1834188 | — | — | 1 | 6.40 |
| CHEMBL1834193 | — | — | 1 | 6.38 |
| CHEMBL1834045 | — | — | 1 | 6.38 |
| CHEMBL1834044 | — | — | 1 | 6.32 |
| CHEMBL1834196 | — | — | 1 | 6.28 |
| CHEMBL1834198 | — | — | 1 | 6.24 |
| CHEMBL1834189 | — | — | 1 | 6.16 |
| CHEMBL1834195 | — | — | 1 | 6.04 |
| CHEMBL1834186 | — | — | 1 | 5.89 |
| CHEMBL1834190 | — | — | 1 | 5.85 |
| CHEMBL1834187 | — | — | 1 | 5.82 |
| CHEMBL1834178 | — | — | 1 | 5.82 |
| CHEMBL1834180 | — | — | 1 | 5.70 |
| CHEMBL1834191 | — | — | 1 | 5.62 |
| CHEMBL45627 | CERULENIN | — | 1 | 5.24 |
| CHEMBL1834181 | — | — | 1 | - |
| CHEMBL1834199 | BI 99990 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1834184 | BI 99179 | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1834182 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1834192 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1834194 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1834197 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1834185 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1834179 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1834183 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1834188 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1834193 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1834045 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1834044 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1834196 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1834198 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL1834189 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1834195 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL1834186 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1834190 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1834187 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1834178 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1834180 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1834191 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL45627 | CERULENIN | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1834181 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1834199 | BI 99990 | IC50 | > | 3000.0 | nM | - |