Assay Detail
Binding
CHEMBL1839617
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Inhibition of BRK pretreated for 30 mins by microplate reader
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 67 | 7.48 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1836842 | — | — | 1 | 8.70 |
| CHEMBL1836806 | — | — | 1 | 8.52 |
| CHEMBL1836844 | — | — | 1 | 8.52 |
| CHEMBL1836854 | — | — | 1 | 8.52 |
| CHEMBL1836863 | — | — | 1 | 8.52 |
| CHEMBL1836846 | — | — | 1 | 8.30 |
| CHEMBL1836755 | — | — | 1 | 8.22 |
| CHEMBL1836865 | — | — | 1 | 8.22 |
| CHEMBL1836840 | — | — | 1 | 8.15 |
| CHEMBL1836867 | — | — | 1 | 8.15 |
| CHEMBL1836802 | — | — | 1 | 8.15 |
| CHEMBL1836810 | — | — | 1 | 8.10 |
| CHEMBL1836805 | — | — | 1 | 8.10 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 8.05 |
| CHEMBL1836862 | — | — | 1 | 8.05 |
| CHEMBL1836754 | — | — | 1 | 8.00 |
| CHEMBL1836864 | — | — | 1 | 8.00 |
| CHEMBL1836853 | — | — | 1 | 8.00 |
| CHEMBL1836847 | — | — | 1 | 8.00 |
| CHEMBL1836843 | — | — | 1 | 8.00 |
| CHEMBL1836815 | — | — | 1 | 8.00 |
| CHEMBL1836799 | — | — | 1 | 8.00 |
| CHEMBL1836760 | — | — | 1 | 8.00 |
| CHEMBL1836796 | — | — | 1 | 7.96 |
| CHEMBL1836841 | — | — | 1 | 7.96 |
| CHEMBL1836761 | — | — | 1 | 7.92 |
| CHEMBL1739550 | — | — | 1 | 7.89 |
| CHEMBL1836845 | — | — | 1 | 7.89 |
| CHEMBL1836800 | — | — | 1 | 7.82 |
| CHEMBL1836837 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1836842 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1836806 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1836863 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1836844 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1836854 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1836846 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1836755 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1836865 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1836802 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1836840 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1836867 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1836810 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1836805 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1836862 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1836754 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1836760 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1836799 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1836815 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1836843 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1836847 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1836853 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1836864 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1836796 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1836841 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1836761 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1836845 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1739550 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1836800 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1836837 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1836807 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1836838 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1836839 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1836803 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1836861 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1836801 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1836814 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1836804 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1836748 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1836813 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1836850 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1836849 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1836808 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1836855 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1836812 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1836797 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1836809 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1836757 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1836758 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL1836848 | — | IC50 | = | 124.0 | nM | 6.91 |