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Assay Detail

CHEMBL1839618

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of phosphorylation of SAM68 in 293 WT-PTK6 cells after 3 hrs
ChEMBL ↗
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type 293 WT-PTK6
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Protein-tyrosine kinase 6 (CHEMBL4601) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.
Zeng H, Belanger DB, Curran PJ, Shipps GW, Miao H, Bracken JB, Arshad Siddiqui M, Malkowski M, Wang Y.
Bioorg Med Chem Lett (2011) 21 : 5870 -5875
PubMed 21855335 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 65 7.28 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1836842 — — 1 8.30
CHEMBL1836863 — — 1 8.15
CHEMBL1836854 — — 1 8.15
CHEMBL1836843 — — 1 7.85
CHEMBL1836847 — — 1 7.77
CHEMBL1836838 — — 1 7.72
CHEMBL1836803 — — 1 7.66
CHEMBL1836755 — — 1 7.66
CHEMBL1836815 — — 1 7.64
CHEMBL1836845 — — 1 7.48
CHEMBL1836802 — — 1 7.46
CHEMBL1836754 — — 1 7.42
CHEMBL1836864 — — 1 7.42
CHEMBL1836804 — — 1 7.40
CHEMBL1836837 — — 1 7.38
CHEMBL1836846 — — 1 7.35
CHEMBL1836862 — — 1 7.34
CHEMBL1836840 — — 1 7.33
CHEMBL1836844 — — 1 7.33
CHEMBL1836861 — — 1 7.28
CHEMBL1836853 — — 1 7.27
CHEMBL1836839 — — 1 7.21
CHEMBL1739550 — — 1 7.03
CHEMBL1836796 — — 1 6.96
CHEMBL1836814 — — 1 6.95
CHEMBL1836812 — — 1 6.92
CHEMBL1836808 — — 1 6.88
CHEMBL1836813 — — 1 6.86
CHEMBL1836801 — — 1 6.82
CHEMBL1836867 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1836842 — IC50 = 5.0 nM 8.30
CHEMBL1836863 — IC50 = 7.0 nM 8.15
CHEMBL1836854 — IC50 = 7.0 nM 8.15
CHEMBL1836843 — IC50 = 14.0 nM 7.85
CHEMBL1836847 — IC50 = 17.0 nM 7.77
CHEMBL1836838 — IC50 = 19.0 nM 7.72
CHEMBL1836803 — IC50 = 22.0 nM 7.66
CHEMBL1836755 — IC50 = 22.0 nM 7.66
CHEMBL1836815 — IC50 = 23.0 nM 7.64
CHEMBL1836845 — IC50 = 33.0 nM 7.48
CHEMBL1836802 — IC50 = 35.0 nM 7.46
CHEMBL1836754 — IC50 = 38.0 nM 7.42
CHEMBL1836864 — IC50 = 38.0 nM 7.42
CHEMBL1836804 — IC50 = 40.0 nM 7.40
CHEMBL1836837 — IC50 = 42.0 nM 7.38
CHEMBL1836846 — IC50 = 45.0 nM 7.35
CHEMBL1836862 — IC50 = 46.0 nM 7.34
CHEMBL1836840 — IC50 = 47.0 nM 7.33
CHEMBL1836844 — IC50 = 47.0 nM 7.33
CHEMBL1836861 — IC50 = 52.0 nM 7.28
CHEMBL1836853 — IC50 = 54.0 nM 7.27
CHEMBL1836839 — IC50 = 62.0 nM 7.21
CHEMBL1739550 — IC50 = 94.0 nM 7.03
CHEMBL1836796 — IC50 = 109.0 nM 6.96
CHEMBL1836814 — IC50 = 113.0 nM 6.95
CHEMBL1836812 — IC50 = 120.0 nM 6.92
CHEMBL1836808 — IC50 = 132.0 nM 6.88
CHEMBL1836813 — IC50 = 137.0 nM 6.86
CHEMBL1836801 — IC50 = 153.0 nM 6.82
CHEMBL1836867 — IC50 = 157.0 nM 6.80
CHEMBL1836800 — IC50 = 167.0 nM 6.78
CHEMBL1836841 — IC50 = 177.0 nM 6.75
CHEMBL1836797 — IC50 = 244.0 nM 6.61
CHEMBL1836810 — IC50 = 254.0 nM 6.59
CHEMBL1836809 — IC50 = 608.0 nM 6.22
CHEMBL1836759 — IC50 - — -
CHEMBL1836758 — IC50 - — -
CHEMBL1836757 — IC50 - — -
CHEMBL1836756 — IC50 - — -
CHEMBL1836753 — IC50 - — -
CHEMBL1836752 — IC50 - — -
CHEMBL1836751 — IC50 - — -
CHEMBL1836750 — IC50 - — -
CHEMBL1836749 — IC50 - — -
CHEMBL1836748 — IC50 - — -
CHEMBL1836746 — IC50 - — -
CHEMBL1836745 — IC50 - — -
CHEMBL1836744 — IC50 - — -
CHEMBL1836743 — IC50 - — -
CHEMBL1836760 — IC50 - — -