Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1839620

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of LCK
ChEMBL ↗
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase Lck (CHEMBL258) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.
Zeng H, Belanger DB, Curran PJ, Shipps GW, Miao H, Bracken JB, Arshad Siddiqui M, Malkowski M, Wang Y.
Bioorg Med Chem Lett (2011) 21 : 5870 -5875
PubMed 21855335 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 56 6.18 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5416410 DASATINIB 4.0 1 8.52
CHEMBL1836813 — — 1 8.00
CHEMBL1836814 — — 1 7.16
CHEMBL1836804 — — 1 6.77
CHEMBL1836842 — — 1 6.75
CHEMBL1836846 — — 1 6.55
CHEMBL1836760 — — 1 6.48
CHEMBL1836847 — — 1 6.44
CHEMBL1836867 — — 1 6.38
CHEMBL1836844 — — 1 6.32
CHEMBL1836839 — — 1 6.27
CHEMBL1836843 — — 1 6.22
CHEMBL1836800 — — 1 6.22
CHEMBL1836754 — — 1 6.14
CHEMBL1836802 — — 1 6.14
CHEMBL1836845 — — 1 6.03
CHEMBL1836808 — — 1 5.92
CHEMBL1836840 — — 1 5.82
CHEMBL1836755 — — 1 5.74
CHEMBL1836810 — — 1 5.70
CHEMBL1836815 — — 1 5.65
CHEMBL1836841 — — 1 5.49
CHEMBL1836838 — — 1 5.47
CHEMBL1836796 — — 1 5.43
CHEMBL1836837 — — 1 5.33
CHEMBL1836848 — — 1 4.98
CHEMBL1836863 — — 1 4.85
CHEMBL1836865 — — 1 -
CHEMBL1836807 — — 1 -
CHEMBL1836756 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5416410 DASATINIB IC50 = 3.0 nM 8.52
CHEMBL1836813 — IC50 = 10.0 nM 8.00
CHEMBL1836814 — IC50 = 70.0 nM 7.16
CHEMBL1836804 — IC50 = 169.0 nM 6.77
CHEMBL1836842 — IC50 = 180.0 nM 6.75
CHEMBL1836846 — IC50 = 284.0 nM 6.55
CHEMBL1836760 — IC50 = 330.0 nM 6.48
CHEMBL1836847 — IC50 = 365.0 nM 6.44
CHEMBL1836867 — IC50 = 420.0 nM 6.38
CHEMBL1836844 — IC50 = 476.0 nM 6.32
CHEMBL1836839 — IC50 = 539.0 nM 6.27
CHEMBL1836843 — IC50 = 597.0 nM 6.22
CHEMBL1836800 — IC50 = 603.0 nM 6.22
CHEMBL1836802 — IC50 = 722.0 nM 6.14
CHEMBL1836754 — IC50 = 722.0 nM 6.14
CHEMBL1836845 — IC50 = 945.0 nM 6.03
CHEMBL1836808 — IC50 = 1200.0 nM 5.92
CHEMBL1836840 — IC50 = 1501.0 nM 5.82
CHEMBL1836755 — IC50 = 1830.0 nM 5.74
CHEMBL1836810 — IC50 = 2000.0 nM 5.70
CHEMBL1836815 — IC50 = 2262.0 nM 5.65
CHEMBL1836841 — IC50 = 3208.0 nM 5.49
CHEMBL1836838 — IC50 = 3417.0 nM 5.47
CHEMBL1836796 — IC50 = 3710.0 nM 5.43
CHEMBL1836837 — IC50 = 4648.0 nM 5.33
CHEMBL1836848 — IC50 = 10400.0 nM 4.98
CHEMBL1836863 — IC50 = 14114.0 nM 4.85
CHEMBL1836801 — IC50 - — -
CHEMBL1836852 — IC50 > 20000.0 nM -
CHEMBL1836851 — IC50 > 20000.0 nM -
CHEMBL1836850 — IC50 > 20000.0 nM -
CHEMBL1836849 — IC50 > 20000.0 nM -
CHEMBL1836812 — IC50 - — -
CHEMBL1836811 — IC50 - — -
CHEMBL1836809 — IC50 - — -
CHEMBL1836753 — IC50 - — -
CHEMBL1836806 — IC50 - — -
CHEMBL1836805 — IC50 - — -
CHEMBL1836803 — IC50 - — -
CHEMBL1836799 — IC50 - — -
CHEMBL1739550 — IC50 - — -
CHEMBL1836798 — IC50 - — -
CHEMBL1836797 — IC50 - — -
CHEMBL1836761 — IC50 - — -
CHEMBL1836759 — IC50 - — -
CHEMBL1836758 — IC50 - — -
CHEMBL1836757 — IC50 - — -
CHEMBL1836756 — IC50 - — -
CHEMBL1836807 — IC50 - — -
CHEMBL1836865 — IC50 > 20000.0 nM -