Assay Detail
Functional
CHEMBL1839840
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Cytotoxicity against human MV411 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of a novel dual FMS-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.72 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835867 | — | — | 1 | 9.52 |
| CHEMBL1835749 | — | — | 1 | 9.05 |
| CHEMBL1835750 | — | — | 1 | 9.00 |
| CHEMBL1835869 | — | — | 1 | 9.00 |
| CHEMBL1835871 | — | — | 1 | 9.00 |
| CHEMBL1835747 | — | — | 1 | 8.70 |
| CHEMBL1835748 | — | — | 1 | 8.70 |
| CHEMBL1835863 | — | — | 1 | 8.70 |
| CHEMBL1835866 | — | — | 1 | 7.82 |
| CHEMBL1835865 | — | — | 1 | 7.75 |
| CHEMBL1835868 | — | — | 1 | - |
| CHEMBL1835870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835867 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1835749 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1835750 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1835869 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1835871 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1835747 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1835748 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1835863 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1835866 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1835865 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1835868 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL1835870 | — | IC50 | < | 0.2 | nM | - |