Assay Detail

CHEMBL1839938

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Functional

Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay

ChEMBL ↗

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Target

SMMC-7721 (CHEMBL613831) ↗

Open DB target context

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SMMC-7721 (CHEMBL613831) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SMMC-7721

CHEMBL613831

Anchored from Assay target.

Protein identity SMMC-7721

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SMMC-7721
Confidence	1 — Organism
Curated By	Autocuration

Target

SMMC-7721 (CHEMBL613831) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Biologically active arborinane-type triterpenoids and anthraquinones from Rubia yunnanensis.

Fan JT, Kuang B, Zeng GZ, Zhao SM, Ji CJ, Zhang YM, Tan NH.
J Nat Prod (2011) 74 : 2069 -2080
PubMed 21973054 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.95	8.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL65	CAMPTOTHECIN	-1.0	1	8.52
CHEMBL106562	2-Methoxy-1,4-naphthoquinone	—	1	5.37

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL65	CAMPTOTHECIN	IC50	=	3.0	nM	8.52
CHEMBL106562	2-Methoxy-1,4-naphthoquinone	IC50	=	4300.0	nM	5.37