Assay Detail
Functional
CHEMBL1840103
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human O positive erythrocytes after 48 hrs by SYBR green-I based fluorescence assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.55 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.00 |
| CHEMBL207517 | — | — | 1 | 7.22 |
| CHEMBL207179 | — | — | 1 | 7.22 |
| CHEMBL302007 | — | — | 1 | 6.92 |
| CHEMBL63840 | — | — | 1 | 6.62 |
| CHEMBL208338 | — | — | 1 | 6.52 |
| CHEMBL70227 | — | — | 1 | 5.83 |
| CHEMBL65846 | — | — | 1 | 5.66 |
| CHEMBL248405 | — | — | 1 | 5.38 |
| CHEMBL1834940 | — | — | 1 | 5.18 |
| CHEMBL1834886 | — | — | 1 | 5.08 |
| CHEMBL377233 | — | — | 1 | 5.06 |
| CHEMBL1834947 | — | — | 1 | 5.00 |
| CHEMBL1834941 | — | — | 1 | 4.87 |
| CHEMBL1834946 | — | — | 1 | 4.86 |
| CHEMBL207335 | — | — | 1 | 4.82 |
| CHEMBL1834943 | — | — | 1 | 4.81 |
| CHEMBL378488 | — | — | 1 | 4.79 |
| CHEMBL1834939 | — | — | 1 | 4.71 |
| CHEMBL65260 | — | — | 1 | 4.56 |
| CHEMBL1834888 | — | — | 1 | 4.48 |
| CHEMBL66573 | — | — | 1 | 4.42 |
| CHEMBL1834938 | — | — | 1 | - |
| CHEMBL1834937 | — | — | 1 | - |
| CHEMBL1834942 | — | — | 1 | - |
| CHEMBL1834887 | — | — | 1 | - |
| CHEMBL1834944 | — | — | 1 | - |
| CHEMBL1834945 | — | — | 1 | - |
| CHEMBL1834885 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL207517 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL207179 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL302007 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL63840 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL208338 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL70227 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL65846 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL248405 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1834940 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1834886 | — | IC50 | = | 8360.0 | nM | 5.08 |
| CHEMBL377233 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1834947 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1834941 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1834946 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL207335 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL1834943 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL378488 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL1834939 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL65260 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL1834888 | — | IC50 | = | 33300.0 | nM | 4.48 |
| CHEMBL66573 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL1834938 | — | IC50 | > | 35000.0 | nM | - |
| CHEMBL1834937 | — | IC50 | > | 35000.0 | nM | - |
| CHEMBL1834942 | — | IC50 | > | 27000.0 | nM | - |
| CHEMBL1834887 | — | IC50 | > | 35000.0 | nM | - |
| CHEMBL1834944 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1834945 | — | IC50 | - | — | - | |
| CHEMBL1834885 | — | IC50 | > | 35000.0 | nM | - |