Assay Detail
Binding
CHEMBL1840410
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Inhibition of Aurora A by spectrophotometry
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of a novel dual FMS-like tyrosine kinase 3/stem cell factor receptor (FLT3/c-KIT) inhibitor for the treatment of acute myelogenous leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.99 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835740 | — | — | 1 | 6.99 |
| CHEMBL1835742 | — | — | 1 | 5.70 |
| CHEMBL1835746 | — | — | 1 | 5.68 |
| CHEMBL1835745 | — | — | 1 | 5.58 |
| CHEMBL1835741 | — | — | 1 | - |
| CHEMBL1833992 | — | — | 1 | - |
| CHEMBL1835743 | — | — | 1 | - |
| CHEMBL1835744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835740 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL1835742 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL1835746 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1835745 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL1835741 | — | Ki | > | 7000.0 | nM | - |
| CHEMBL1833992 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL1835743 | — | Ki | > | 3000.0 | nM | - |
| CHEMBL1835744 | — | Ki | > | 2500.0 | nM | - |