Assay Detail
Binding
CHEMBL1908145
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Inhibition of mycophenolic acid (1 mM) glucuronidation by human UGT enzymes from liver microsomes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
UDP-glucuronosyltransferases and clinical drug-drug interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.67 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63323 | NIFLUMIC ACID | 2.0 | 1 | 5.10 |
| CHEMBL23588 | FLUFENAMIC ACID | 2.0 | 1 | 4.72 |
| CHEMBL686 | MEFENAMIC ACID | 4.0 | 1 | 4.20 |
| CHEMBL898 | DIFLUNISAL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63323 | NIFLUMIC ACID | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL23588 | FLUFENAMIC ACID | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL686 | MEFENAMIC ACID | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL898 | DIFLUNISAL | IC50 | = | 109000.0 | nM | - |