Assay Detail
ADMET
CHEMBL1908258
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Mechanism based inhibition of rat cytochrome P450 CYP1A2 measured by 7-methoxyresorufin O-demethylation (MROD)
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.98 | 8.40 |
| kinact | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3215311 | — | — | 2 | 8.40 |
| CHEMBL1908227 | — | — | 2 | 7.52 |
| CHEMBL374163 | — | — | 2 | 6.06 |
| CHEMBL1908231 | — | — | 2 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3215311 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1908227 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL374163 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL1908231 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL374163 | — | kinact | = | 0.1 | min-1 | - |
| CHEMBL1908227 | — | kinact | = | 0.04 | min-1 | - |
| CHEMBL1908231 | — | kinact | = | 0.3 | min-1 | - |
| CHEMBL3215311 | — | kinact | = | 0.06 | min-1 | - |