Assay Detail
Binding
CHEMBL1909108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.36 | 8.77 |
| Ki | 871 | 6.70 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1909065 | MADURAMICIN ACID | 2.0 | 2 | 9.10 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 9.02 |
| CHEMBL1201356 | METHYLERGONOVINE | 4.0 | 2 | 8.93 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 2 | 8.83 |
| CHEMBL119443 | ERGONOVINE | 3.0 | 2 | 8.82 |
| CHEMBL42 | CLOZAPINE | 4.0 | 2 | 8.30 |
| CHEMBL157138 | LISURIDE | 3.0 | 2 | 8.26 |
| CHEMBL715 | OLANZAPINE | 4.0 | 2 | 8.21 |
| CHEMBL1385840 | ERGOCORNINE | — | 2 | 8.15 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 2 | 8.12 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 2 | 8.00 |
| CHEMBL19215 | METERGOLINE | 2.0 | 2 | 7.89 |
| CHEMBL531 | PERGOLIDE | 4.0 | 2 | 7.75 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | — | 2 | 7.72 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 7.62 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 7.58 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 2 | 7.48 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 2 | 7.46 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 2 | 7.44 |
| CHEMBL6437 | MIANSERIN | 4.0 | 2 | 7.40 |
| CHEMBL1909072 | PIPAMAZINE | 4.0 | 2 | 7.28 |
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 2 | 7.19 |
| CHEMBL1065 | METHYSERGIDE | 4.0 | 2 | 7.12 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 2 | 6.94 |
| CHEMBL728 | PROCHLORPERAZINE | 4.0 | 2 | 6.91 |
| CHEMBL564 | PROMAZINE | 4.0 | 2 | 6.90 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 2 | 6.89 |
| CHEMBL1628227 | DOXEPIN | 4.0 | 2 | 6.83 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 2 | 6.59 |
| CHEMBL1255834 | BW-723C86 | — | 2 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1909065 | MADURAMICIN ACID | Ki | = | 0.789 | nM | 9.10 |
| CHEMBL442 | ERGOTAMINE | Ki | = | 0.948 | nM | 9.02 |
| CHEMBL1201356 | METHYLERGONOVINE | Ki | = | 1.178 | nM | 8.93 |
| CHEMBL1732 | DIHYDROERGOTAMINE | Ki | = | 1.486 | nM | 8.83 |
| CHEMBL119443 | ERGONOVINE | Ki | = | 1.503 | nM | 8.82 |
| CHEMBL1909065 | MADURAMICIN ACID | IC50 | = | 1.699 | nM | 8.77 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 2.042 | nM | 8.69 |
| CHEMBL1201356 | METHYLERGONOVINE | IC50 | = | 2.538 | nM | 8.60 |
| CHEMBL1732 | DIHYDROERGOTAMINE | IC50 | = | 3.201 | nM | 8.49 |
| CHEMBL119443 | ERGONOVINE | IC50 | = | 3.237 | nM | 8.49 |
| CHEMBL42 | CLOZAPINE | Ki | = | 5.055 | nM | 8.30 |
| CHEMBL157138 | LISURIDE | Ki | = | 5.514 | nM | 8.26 |
| CHEMBL715 | OLANZAPINE | Ki | = | 6.109 | nM | 8.21 |
| CHEMBL1385840 | ERGOCORNINE | Ki | = | 7.093 | nM | 8.15 |
| CHEMBL1403281 | ERGOCRYPTINE | Ki | = | 7.559 | nM | 8.12 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL157138 | LISURIDE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL19215 | METERGOLINE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL715 | OLANZAPINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1385840 | ERGOCORNINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1403281 | ERGOCRYPTINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL531 | PERGOLIDE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL19215 | METERGOLINE | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL479 | THIORIDAZINE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL1113 | AMOXAPINE | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL6437 | MIANSERIN | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1909072 | PIPAMAZINE | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL629 | AMITRIPTYLINE | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1113 | AMOXAPINE | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL1065 | METHYSERGIDE | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL1626 | CLEMASTINE | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL6437 | MIANSERIN | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1909072 | PIPAMAZINE | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL728 | PROCHLORPERAZINE | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL564 | PROMAZINE | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1628227 | DOXEPIN | Ki | = | 149.0 | nM | 6.83 |