Assay Detail
Binding
CHEMBL1909140
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DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.60 | 8.83 |
| Ki | 871 | 7.08 | 9.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | — | 2 | 9.31 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 2 | 9.28 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 9.27 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 2 | 9.19 |
| CHEMBL1108 | DROPERIDOL | 4.0 | 2 | 9.10 |
| CHEMBL219916 | DOMPERIDONE | 3.0 | 2 | 9.05 |
| CHEMBL157138 | LISURIDE | 3.0 | 2 | 9.02 |
| CHEMBL1909072 | PIPAMAZINE | 4.0 | 2 | 8.87 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 8.84 |
| CHEMBL1385840 | ERGOCORNINE | — | 2 | 8.78 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 2 | 8.66 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 2 | 8.53 |
| CHEMBL728 | PROCHLORPERAZINE | 4.0 | 2 | 8.44 |
| CHEMBL85 | RISPERIDONE | 4.0 | 2 | 8.18 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 2 | 7.92 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 7.75 |
| CHEMBL19215 | METERGOLINE | 2.0 | 2 | 7.68 |
| CHEMBL531 | PERGOLIDE | 4.0 | 2 | 7.43 |
| CHEMBL715 | OLANZAPINE | 4.0 | 2 | 7.41 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 2 | 7.38 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 2 | 7.37 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 2 | 7.35 |
| CHEMBL723 | CARVEDILOL | 4.0 | 2 | 7.31 |
| CHEMBL1221512 | — | — | 2 | 7.28 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 2 | 7.26 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 2 | 7.17 |
| CHEMBL26 | SULPIRIDE | 3.0 | 2 | 7.17 |
| CHEMBL49 | BUSPIRONE | 4.0 | 2 | 6.97 |
| CHEMBL30008 | FLUNARIZINE | 2.0 | 2 | 6.93 |
| CHEMBL42 | CLOZAPINE | 4.0 | 2 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | Ki | = | 0.491 | nM | 9.31 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 0.527 | nM | 9.28 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 0.539 | nM | 9.27 |
| CHEMBL1403281 | ERGOCRYPTINE | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL1108 | DROPERIDOL | Ki | = | 0.802 | nM | 9.10 |
| CHEMBL219916 | DOMPERIDONE | Ki | = | 0.882 | nM | 9.05 |
| CHEMBL157138 | LISURIDE | Ki | = | 0.953 | nM | 9.02 |
| CHEMBL1909072 | PIPAMAZINE | Ki | = | 1.35 | nM | 8.87 |
| CHEMBL442 | ERGOTAMINE | Ki | = | 1.433 | nM | 8.84 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | IC50 | = | 1.474 | nM | 8.83 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 1.582 | nM | 8.80 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 1.616 | nM | 8.79 |
| CHEMBL1385840 | ERGOCORNINE | Ki | = | 1.677 | nM | 8.78 |
| CHEMBL1403281 | ERGOCRYPTINE | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.197 | nM | 8.66 |
| CHEMBL1108 | DROPERIDOL | IC50 | = | 2.407 | nM | 8.62 |
| CHEMBL219916 | DOMPERIDONE | IC50 | = | 2.647 | nM | 8.58 |
| CHEMBL157138 | LISURIDE | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL1732 | DIHYDROERGOTAMINE | Ki | = | 2.96 | nM | 8.53 |
| CHEMBL728 | PROCHLORPERAZINE | Ki | = | 3.608 | nM | 8.44 |
| CHEMBL1909072 | PIPAMAZINE | IC50 | = | 4.05 | nM | 8.39 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1385840 | ERGOCORNINE | IC50 | = | 5.032 | nM | 8.30 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 6.592 | nM | 8.18 |
| CHEMBL85 | RISPERIDONE | Ki | = | 6.545 | nM | 8.18 |
| CHEMBL1732 | DIHYDROERGOTAMINE | IC50 | = | 8.88 | nM | 8.05 |
| CHEMBL728 | PROCHLORPERAZINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL479 | THIORIDAZINE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL19215 | METERGOLINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL531 | PERGOLIDE | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL715 | OLANZAPINE | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL723 | CARVEDILOL | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL1221512 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL19215 | METERGOLINE | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL26 | SULPIRIDE | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL1113 | AMOXAPINE | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL49 | BUSPIRONE | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL715 | OLANZAPINE | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL30008 | FLUNARIZINE | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL42 | CLOZAPINE | Ki | = | 129.0 | nM | 6.89 |