Assay Detail
Binding
CHEMBL1909141
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DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 6.55 | 9.76 |
| Ki | 871 | 6.99 | 10.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | 3.0 | 2 | 10.23 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 2 | 9.70 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 2 | 9.70 |
| CHEMBL726 | FLUPHENAZINE | 4.0 | 2 | 9.70 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | — | 2 | 9.11 |
| CHEMBL1108 | DROPERIDOL | 4.0 | 2 | 9.03 |
| CHEMBL1385840 | ERGOCORNINE | — | 2 | 9.01 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 2 | 8.83 |
| CHEMBL1909072 | PIPAMAZINE | 4.0 | 2 | 8.80 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 2 | 8.74 |
| CHEMBL531 | PERGOLIDE | 4.0 | 2 | 8.74 |
| CHEMBL1626 | CLEMASTINE | 4.0 | 2 | 8.60 |
| CHEMBL19215 | METERGOLINE | 2.0 | 2 | 8.58 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 2 | 8.47 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 2 | 8.38 |
| CHEMBL728 | PROCHLORPERAZINE | 4.0 | 2 | 8.35 |
| CHEMBL219916 | DOMPERIDONE | 3.0 | 2 | 8.21 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 2 | 8.16 |
| CHEMBL85 | RISPERIDONE | 4.0 | 2 | 8.10 |
| CHEMBL1909065 | MADURAMICIN ACID | 2.0 | 2 | 8.03 |
| CHEMBL1221512 | — | — | 2 | 8.02 |
| CHEMBL49 | BUSPIRONE | 4.0 | 2 | 7.82 |
| CHEMBL516 | CYPROHEPTADINE | 4.0 | 2 | 7.80 |
| CHEMBL715 | OLANZAPINE | 4.0 | 2 | 7.57 |
| CHEMBL508338 | THIMEROSAL | 3.0 | 2 | 7.54 |
| CHEMBL30008 | FLUNARIZINE | 2.0 | 2 | 7.48 |
| CHEMBL305660 | EBASTINE | 4.0 | 2 | 7.38 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 2 | 7.38 |
| CHEMBL1113 | AMOXAPINE | 4.0 | 2 | 7.34 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 2 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157138 | LISURIDE | Ki | = | 0.059 | nM | 10.23 |
| CHEMBL157138 | LISURIDE | IC50 | = | 0.173 | nM | 9.76 |
| CHEMBL1403281 | ERGOCRYPTINE | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL726 | FLUPHENAZINE | Ki | = | 0.202 | nM | 9.70 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 0.202 | nM | 9.70 |
| CHEMBL1403281 | ERGOCRYPTINE | IC50 | = | 0.589 | nM | 9.23 |
| CHEMBL726 | FLUPHENAZINE | IC50 | = | 0.594 | nM | 9.23 |
| CHEMBL493 | BROMOCRIPTINE | IC50 | = | 0.596 | nM | 9.22 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | Ki | = | 0.777 | nM | 9.11 |
| CHEMBL1108 | DROPERIDOL | Ki | = | 0.939 | nM | 9.03 |
| CHEMBL1385840 | ERGOCORNINE | Ki | = | 0.971 | nM | 9.01 |
| CHEMBL442 | ERGOTAMINE | Ki | = | 1.464 | nM | 8.83 |
| CHEMBL1909072 | PIPAMAZINE | Ki | = | 1.586 | nM | 8.80 |
| CHEMBL1732 | DIHYDROERGOTAMINE | Ki | = | 1.812 | nM | 8.74 |
| CHEMBL531 | PERGOLIDE | Ki | = | 1.832 | nM | 8.74 |
| CHEMBL1255837 | DIHYDROERGOCRISTINE MESYLATE | IC50 | = | 2.288 | nM | 8.64 |
| CHEMBL1626 | CLEMASTINE | Ki | = | 2.491 | nM | 8.60 |
| CHEMBL19215 | METERGOLINE | Ki | = | 2.611 | nM | 8.58 |
| CHEMBL1108 | DROPERIDOL | IC50 | = | 2.765 | nM | 8.56 |
| CHEMBL1385840 | ERGOCORNINE | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL479 | THIORIDAZINE | Ki | = | 3.36 | nM | 8.47 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 4.205 | nM | 8.38 |
| CHEMBL442 | ERGOTAMINE | IC50 | = | 4.311 | nM | 8.37 |
| CHEMBL728 | PROCHLORPERAZINE | Ki | = | 4.454 | nM | 8.35 |
| CHEMBL1909072 | PIPAMAZINE | IC50 | = | 4.671 | nM | 8.33 |
| CHEMBL1732 | DIHYDROERGOTAMINE | IC50 | = | 5.336 | nM | 8.27 |
| CHEMBL531 | PERGOLIDE | IC50 | = | 5.393 | nM | 8.27 |
| CHEMBL219916 | DOMPERIDONE | Ki | = | 6.243 | nM | 8.21 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 6.842 | nM | 8.16 |
| CHEMBL1626 | CLEMASTINE | IC50 | = | 7.335 | nM | 8.13 |
| CHEMBL19215 | METERGOLINE | IC50 | = | 7.689 | nM | 8.11 |
| CHEMBL85 | RISPERIDONE | Ki | = | 8.036 | nM | 8.10 |
| CHEMBL1909065 | MADURAMICIN ACID | Ki | = | 9.336 | nM | 8.03 |
| CHEMBL1221512 | — | Ki | = | 9.635 | nM | 8.02 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 9.892 | nM | 8.01 |
| CHEMBL71 | CHLORPROMAZINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL728 | PROCHLORPERAZINE | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL49 | BUSPIRONE | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL516 | CYPROHEPTADINE | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL219916 | DOMPERIDONE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL85 | RISPERIDONE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL715 | OLANZAPINE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL1909065 | MADURAMICIN ACID | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1221512 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL508338 | THIMEROSAL | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL30008 | FLUNARIZINE | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL305660 | EBASTINE | Ki | = | 41.3 | nM | 7.38 |
| CHEMBL49 | BUSPIRONE | IC50 | = | 44.0 | nM | 7.36 |