Assay Detail
Binding
CHEMBL1912299
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-epibatidine from Bulinus truncatus N-terminal FLAG-tagged AChBP F149L mutant expressed in HEK293 cells after 2 hrs by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bulinus truncatus |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of related α7 selective ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.35 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162395 | — | — | 1 | 7.66 |
| CHEMBL1163383 | — | — | 1 | 7.48 |
| CHEMBL134713 | GTS-21 | 2.0 | 1 | 7.23 |
| CHEMBL1165604 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162395 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL1163383 | — | Kd | = | 33.0 | nM | 7.48 |
| CHEMBL134713 | GTS-21 | Kd | = | 59.0 | nM | 7.23 |
| CHEMBL1165604 | — | Kd | = | 93.0 | nM | 7.03 |