Assay Detail
Functional
CHEMBL1912441
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Cytotoxicity against human A549 cells by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Solvent-free, microwave assisted Knoevenagel condensation of novel 2,5-disubstituted indole analogues and their biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.97 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.16 |
| CHEMBL1910511 | — | — | 1 | 6.00 |
| CHEMBL1910512 | — | — | 1 | 5.47 |
| CHEMBL1910508 | — | — | 1 | 5.35 |
| CHEMBL1910510 | — | — | 1 | 5.11 |
| CHEMBL1910505 | — | — | 1 | 4.57 |
| CHEMBL1910506 | — | — | 1 | 4.56 |
| CHEMBL1714005 | — | — | 1 | 4.28 |
| CHEMBL466441 | — | — | 1 | 4.11 |
| CHEMBL1910509 | — | — | 1 | 4.06 |
| CHEMBL1910504 | — | — | 1 | - |
| CHEMBL1909650 | — | — | 1 | - |
| CHEMBL1910507 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1910511 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1910512 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1910508 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1910510 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1910505 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1910506 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL1714005 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL466441 | — | IC50 | = | 77400.0 | nM | 4.11 |
| CHEMBL1910509 | — | IC50 | = | 87700.0 | nM | 4.06 |
| CHEMBL1910504 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1909650 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1910507 | — | IC50 | > | 100000.0 | nM | - |