Assay Detail
Functional
CHEMBL1912967
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Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiviral activity of novel 2'-fluoro-6'-methylene-carbocyclic adenosine against wild-type and drug-resistant hepatitis B virus mutants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.63 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | 4.0 | 1 | 8.10 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 6.70 |
| CHEMBL484 | ADEFOVIR | 3.0 | 1 | 5.89 |
| CHEMBL1909862 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5314362 | ENTECAVIR | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL484 | ADEFOVIR | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1909862 | — | EC50 | = | 1500.0 | nM | 5.82 |