Assay Detail
Binding
CHEMBL1913010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-apamin from cloned SK3 channel expressed in human HEK293 cells after 1 hr by liquid scintillation counting
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel protein 3 (CHEMBL3381) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.45 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1909931 | — | — | 1 | 7.34 |
| CHEMBL1909929 | — | — | 1 | 6.67 |
| CHEMBL1909930 | — | — | 1 | 6.24 |
| CHEMBL1909928 | — | — | 1 | 6.08 |
| CHEMBL1909932 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1909931 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL1909929 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL1909930 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL1909928 | — | Ki | = | 837.0 | nM | 6.08 |
| CHEMBL1909932 | — | Ki | = | 1268.0 | nM | 5.90 |