Assay Detail
Functional
CHEMBL1913035
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Antiangiogenic activity against human HUVEC cells assessed as suppression of tube formation after 20 hrs incubation by calcein staining-based fluorescent microscopy
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.27 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216989 | — | — | 1 | 7.16 |
| CHEMBL1911506 | — | — | 1 | 7.10 |
| CHEMBL1911501 | — | — | 1 | 6.96 |
| CHEMBL1911505 | — | — | 1 | 6.57 |
| CHEMBL3216768 | — | — | 1 | 6.54 |
| CHEMBL1911499 | — | — | 1 | 5.00 |
| CHEMBL1911503 | — | — | 1 | 4.57 |
| CHEMBL1911504 | — | — | 1 | - |
| CHEMBL1911502 | — | — | 1 | - |
| CHEMBL1911500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216989 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1911506 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1911501 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1911505 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3216768 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1911499 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1911503 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1911504 | — | IC50 | - | — | - | |
| CHEMBL1911502 | — | IC50 | - | — | - | |
| CHEMBL1911500 | — | IC50 | - | — | - |