Assay Detail
ADMET
CHEMBL1913047
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Antiproliferative activity against human ECV304 cells assessed as growth inhibition after 72 hrs by MTT assay
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | ECV-304 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Stable and orally bio-available pro-drugs of CPS11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| GI | 4 | - | - |
| IC50 | 3 | 6.89 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1911509 | — | — | 2 | 7.00 |
| CHEMBL1911510 | — | — | 2 | 6.92 |
| CHEMBL1911511 | — | — | 2 | 6.75 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1911509 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1911510 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1911511 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1911511 | — | GI | - | — | - | |
| CHEMBL1911509 | — | GI | - | — | - | |
| CHEMBL1911510 | — | GI | - | — | - | |
| CHEMBL468 | THALIDOMIDE | GI | = | 40.0 | % | - |